Two SNPs (rs1234314 and rs45454293) in the promoter region of TNFSF4 were associated with the risk for severe GVHD (Table 7) in patients with AML (rs1234314: Trend test, p = 0.006; allele model, p = 0.0114 for C vs. G, OR = 7.39, and 95% CI = 1.58–34.52; and rs45454293: Trend test, p = 0.0145, allele model p = 0.0100 for T vs. C, OR = 4.86, and 95% CI = 1.47–16.07). This evidence concerns the gene TNFSF4 and graft versus host disease.