In this study, we investigated further whether these is an association between 34 donor SNPs in the four co-stimulatory genes (TNFSF4, CTLA4, CD28, and PDCD1) and the occurrence of adverse outcomes (mortality, relapse, CMV infection, and GVHD) for patients with AML and ALL. Here, TNFSF4 is linked to graft versus host disease.