By analyzing a total of 34 SNPs, 4 SNPs (rs733618, rs11571316, and rs3087243 in CTLA-4, and rs41386349 in PDCD1) and 1 SNP (rs11571315) elicited significant recessive allelic effects and contributed to the post-HSCT mortality for patients with AML and ALL, respectively (Table 4). The gene discussed is CTLA4; the disease is acute myeloid leukemia.