In recent years, some studies have indicated that several metabolic enzymes, including enolase and EF-TU of Mhp, which were investigated by our team (Hegde et al., 2015; Yu et al., 2018; Chen et al., 2019), play an important role in host-pathogen interactions during Mycoplasma infections; these findings indicate that the two metabolic enzymes act as virulence proteins in addition to their typical roles. Here, CACNA1A is linked to Mycoplasmoides infection.