Rising interests were drawn in abnormal function of female sex hormone and hormonal receptors of PCOS women, and the impact of the mutation of some critical genes in the hormone metabolism pathways such as androgen receptor (AR) (8), luteinizing hormone receptor (LHR) (9), and follicle-stimulating hormone receptor (FSHR) (10) has been investigated in some meta-analyses. The gene discussed is LHCGR; the disease is polycystic ovary syndrome.