Overexpression of VDAC1 in affected regions of AD brains (Perez-Gracia et al., 2008; Cuadrado-Tejedor et al., 2011; Manczak and Reddy, 2012) and in β-cells of T2D (Ahmed et al., 2010; Gong et al., 2012; Sasaki et al., 2012; Zhang E. et al., 2019) has been reported. The gene discussed is VDAC1; the disease is Alzheimer disease.