VDAC1, by interacting with the anti-apoptotic proteins and HK, protects tumor cells from cell death (Shimizu et al., 1999, 2000; Pastorino et al., 2002, 2005; Pedersen et al., 2002; Shi et al., 2003a,b; Azoulay-Zohar et al., 2004; Zaid et al., 2005; Mathupala et al., 2006; Malia and Wagner, 2007; Abu-Hamad et al., 2008, 2009; Arzoine et al., 2009; Arbel and Shoshan-Barmatz, 2010; Shoshan-Barmatz et al., 2010; Arbel et al., 2012; Geula et al., 2012a). This evidence concerns the gene VDAC1 and neoplasm.