VDAC1 and cancer: VDAC1 is also the most abundant and best studied isoform (De Pinto et al., 2010; Messina et al., 2012; Raghavan et al., 2012), and VDAC2 was reported as a pro-apoptotic protein, interacting with Bax (Roy et al., 2009), yet its effect in apoptosis is controversial (Maurya and Mahalakshmi, 2016), expressed mainly in cancer, but not in the brain.