The overexpression of VDAC1 in various tumors obtained from patients, and in tumors established in mouse models, as well as in cancer cell lines (Arif et al., 2014, 2017; Shoshan-Barmatz et al., 2015, Shoshan-Barmatz et al., 2017a,b; Pittala et al., 2018), points to its significance in high energy-demanding cancer cells. Here, VDAC1 is linked to cancer.