VDAC1 and cancer: Finally, in cancer, VDAC1 (Abu-Hamad et al., 2006; Koren et al., 2010; Arif et al., 2014, 2017; Shoshan-Barmatz et al., 2015, Shoshan-Barmatz et al., 2017a,b; Pittala et al., 2018) and VDAC3 (Jozwiak et al., 2020) are overexpressed, and shown to be essential for cancer development (siRNA).