VDAC1 and neoplasm: Moreover, VDAC1 silencing inhibited tumor growth, modulated the tumor microenvironment, eliminated tumor oncogenic properties (e.g., angiogenesis, stemness), and induced differentiation into normal-like cells (Arif et al., 2014, 2017, 2018, 2019a,b; Amsalem et al., 2020).