VDAC1 and Alzheimer disease: As neuron loss, mainly due to apoptosis, occurs in AD brains (Colurso et al., 2003; Lezi and Swerdlow, 2012; Sabirov and Merzlyak, 2012; Silva et al., 2012; Smilansky et al., 2015) and VDAC1 overexpression induces apoptotic cell death (Godbole et al., 2003; Zaid et al., 2005; Abu-Hamad et al., 2006; Ghosh et al., 2007; Lu et al., 2007; Weisthal et al., 2014), its overexpression in AD and in T2DM may be a common mechanism in these pathologies.