SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Hm1a leads to increased Nav channels availability during high-frequency stimulations and its intracerebroventicular infusion reduced the Dravet syndrome-like phenotype of mice with Nav1.1 haploinsufficiency (Osteen et al., 2016; Richards et al., 2018).