SCN4A and Duchenne muscular dystrophy: The syntrophin-Nav1.4 interaction could modify the gating properties of Nav1.4 and participate to loss of muscle force in some acquired or inherited myopathic conditions, such as critical illness myopathy or Duchenne muscular dystrophy, a disease acquired by patients in intensive care units and an inherited disorder characterized by progressive muscle degeneration and weakness due to the lack of dystrophin, respectively (Teener and Rich, 2006; Hirn et al., 2008; Kraner et al., 2012).