The key targets primarily related to those signaling pathways, such as Proteoglycans in cancer (Fold enrichment = 13.8, p < 0.01) and Rap1 Signaling pathway (Fold enrichment = 13.1, p < 0.01), PI3K-Akt signaling pathway (Fold enrichment = 7.98, p < 0.01) and Ras signaling pathway (Fold enrichment = 9.13, p < 0.05). This evidence concerns the gene AKT1 and cancer.