The ADME-related parameters of the compounds of ARF were predicted and evaluated; 4) protein–protein interaction (PPI) network analyses, the KEGG pathway, and gene ontology (GO) enrichment analyses were performed for key targets; 5) the compound–common target and RA-related pathway networks were developed to investigate the potential mechanisms, and the key targets were selected for subsequent experimental verification in vitro. The gene discussed is CDKN2A; the disease is rheumatoid arthritis.