PRNP and Creutzfeldt Jacob disease: Heparan sulfate GAGs were also present in amyloid plaques in prion (PrP protein) diseases including Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), kuru, and animal scrapie (Snow and Wight, 1989; Snow et al., 1989a, 1990c).