In mesothelioma, the nuclear translocation of the HSPG syndecan-1 was linked to specific points of the cell cycle through interactions with microtubule structures (Brockstedt et al., 2002; Dobra et al., 2003), and drug-induced cell division arrest in the G2 phase inhibited the HSPG syndecan-1 translocation to the nucleus (Zong et al., 2009). This evidence concerns the gene SDC1 and mesothelioma.