Perlecan and other HSPGs are produced by endothelial cells in the walls of blood vessels and contribute to cerebrovascular amyloid deposition in AD (Snow and Wight, 1989; Koyama et al., 1998; Van Horssen, 2001; Kinsella et al., 2003; Hosono-Fukao et al., 2012). This evidence concerns the gene HSPG2 and Alzheimer disease.