The purpose of this study was to investigate the diagnostic performance of CAT for QQ-based OEF mapping and apply DCE-MRI to predict not only the molecular parameters such as IDH1 mutation and MGMT promoter methylation status in glioma but also differentiation of World Health Organization (WHO) grade II/III lower-grade glioma (LGG) vs. WHO grade IV GBM. The gene discussed is MGMT; the disease is glioma.