DP2 involves the activation of multiple neuronal damage pathways, and the classic autophagy inhibitory PI3K/AKT/mTOR pathway may be one of them.To confirm that DP2 is involved in T2D brain injury by activating PI3K/AKT/mTOR to inhibit autophagy, rapamycin and wortmannin were administered to DK-PGD2 and CAY10471, respectively. The gene discussed is AKT1; the disease is type 2 diabetes mellitus.