CD4 and neoplasm: The further research indicats that modification peptides deriving from ENO1 protein can stimulate the CD8+ T cells and CD4+ T cells, peripheral blood mononuclear cells (PBMCs) and tumor infiltrating lymphocytes (TILs) to release cytokine, such as like IFN-γ, TNF-α, as well as the expression of activation marker like CD107a 31.