Given that furin and TMPRSS2 are both proteinases and ACE2 was reported as the main viral receptor for COVID-19, comparison between OS and TMPRSS2, ACE2 and furin was conducted and found that only KIRC and LGG show the same patterns of OS (Figure 8F), demonstrating their ubiquity in different cancers. The gene discussed is TMPRSS2; the disease is COVID-19.