Effect on ACE2, furin, HSPA6 and TMPRSS2 expression due furin mutation revealed that furin might elevate ACE2 expression in LUAD and UCEC, might reduce ACE2 expression in COAD, might elevate HSPA5 expression in PAAD, and might elevate TMPRSS2 expression in BRCA. The gene discussed is TMPRSS2; the disease is colon adenocarcinoma.