PNPLA3 and metabolic dysfunction-associated steatotic liver disease: It is worth mentioning that PNPLA3 rs738409 (C>G), a SNP discovered from a Genome-wide Association Study for NAFLD, has been widely reported as a very strong genetic determinant for the levels of liver fat and ALT 37, 38, however, we were unable to establish any significant association between rs738409 and NAFLD or the measurements on liver function in human subjects in the present study.