LRP6 and metabolic dysfunction-associated steatotic liver disease: However, the plasma levels of aspartate aminotransferase (AST) and alanine transaminase (ALT) were 28.6% and 21.9% lower in the NAFLD subjects carrying LRP6 rs2302685 T allele than those carrying the C allele, respectively (Figure 1B, Table 2), suggesting differential roles of LRP6 in NAFLD risk and its liver injury.