LRP6 and metabolic dysfunction-associated steatotic liver disease: Firstly, the expression of Lrp6, β-catenin and Cyp2e1 in the liver was found to be significantly upregulated in both Lrp6 genotypes of mice with the MCD diet-induced NAFLD relative to those received the MCS diet, respectively (Figure 5A), confirming a role by these proteins in NAFLD.