Because CYP2E1 is considered as one of the major regulators to on hepatic ROS levels during oxidative stress, the Lrp6-Wnt/β-catenin-CYP2E1 signaling axis might be an important mechanism accounting for individual susceptibility to NAFLD 19, 25. The gene discussed is CYP2E1; the disease is metabolic dysfunction-associated steatotic liver disease.