The T allele of LRP6 rs2302685 was significantly associated with a higher risk (OR=2.853; 95% CI, 1.378-5.910; P=0.005) of NAFLD in comparison to the C allele in subjects, while FABP1 rs2241883 (T allele) was significantly associated with a lower risk (OR=0.606; 95% CI, 0.380-0.968; P=0.036) of NAFLD. This evidence concerns the gene LRP6 and metabolic dysfunction-associated steatotic liver disease.