However, among over 500 TCGA samples, ACE2 and AGTR1 were found to be related to OS or DSS, and therefore, they might be used as independent prognostic factors for KIRC; in contrast, ACE2 was related to OS in the E-DKFZ-1 cohort (including data from transcription profiling of 74 kidney tumor samples of different histological types, differentiation grades, and stages and data on chromosomal aberrations and follow-up). The gene discussed is ACE2; the disease is kidney neoplasm.