Several studies in breast, lung, and colon cancer have proposed that the classical axis (ACE/Ang II/AGTR1) can activate multiple downstream signaling pathways (PI3K-AKT, MAPK, and TGF-β) and biological factors to promote tumor cell proliferation, invasion, and anti-apoptosis mechanisms 13, 14. The gene discussed is AGTR1; the disease is malignant colon neoplasm.