In contrast to other members, AGTR1 was distinctly hypermethylated in multiple cancers, such as COAD, head and neck squamous cell carcinoma (HNSC), UCEC, LUSC, and BLCA (Figure 6A), supporting previous studies in COAD 50 and LUSC 51. The gene discussed is AGTR1; the disease is head and neck squamous cell carcinoma.