PCSK1 and neoplasm: Survival curves showed that both PCSK1 and SMOC1 protein expression levels were significantly correlated with the recurrence (Figure 6E, 6F), and double-positive PCSK1/SMOC1 protein expression was the more unfavorable prognostic factor (Figure 6G) than a single marker, tumor size (Figure 6H), and tumor grade (Figure 6I).