As shown in Supplementary Figure S1E, NES was expressed in both two subtypes of primary tumor where subtype 3 predominate, which could be explained, at least in part, that subtype 0 and subtype 3 were two subpopulations located at the early phage of tumor evolution and they may share some gene features with the neural stem cell which they may be derived from. The gene discussed is NES; the disease is neoplasm.