This comprehensive analysis revealed decreases in gene expressions associated with lung development; Foxa2, Notch1, Foxp2, Nkx2.1, and intestine development; Cdx2, Foxf2, Foxl1, and skeletal development; Hoxd12, Hoxd13, Scx, Brachyury, and cleft palate; Foxf2 (Fig. 3a–c). The gene discussed is HOXD12; the disease is cleft palate.