We discovered that Dyrk2−/− mice exhibit defects in the multiorgan development, such as butterfly vertebrae, imperforate anus, the left and right subclavian artery defects, tracheoesophageal stenosis, shortened radial bone, polydactyly, and lung hypoplasia in addition to omphalocele, truncated gastrointestinal tract, hair follicular hypoplasia, cleft palates, and craniofacial abnormalities. This evidence concerns the gene DYRK2 and omphalocele.