PCSK9 and Insulin resistance: While LDL-C significantly decreased from baseline to follow-up (associated with opposite changes in HDL-C and PCSK9), there was a significant increase in TG levels, remnant-C, the TG/HDL-C ratio, together with indexes of insulin resistance (HOMA, Tyg index), systemic inflammation (IL-6) and endothelial activation (VCAM1).