EZH2 and colonic neoplasm: Using the APCmin/+ and AOM/DSS models, we showed that the deletion of the EZH2 gene significantly inhibited the occurrence of colon cancer, indicating a cancer-promoting function of EZH2 in CRC (Supplementary Fig. 3A–H); these results were consistent with the function of EZH2 in other solid cancers [11, 16, 17].