The results showed that glucose deprivation decreased EZH2 mRNA levels in a dose- and time-dependent manner in the glucose-sensitive CRC cell lines HCT116 and SW480 (Fig. 1D, E and Supplementary Fig. 1B, C) but not in the glucose-insensitive cell lines RKO and LoVo (Supplementary Fig. 1D, E). This evidence concerns the gene EZH2 and colorectal carcinoma.