CXCL8 and colonic neoplasm: For instance, in colon cancer, it has been shown that pharmacological inhibition of ERK5 by employing XMD 8-92 inhibitor resulted in decreased IL-8 expression and NF-κB transcriptional activity [70], and also in Jurkat cells it was observed that ERK5 controlled the nuclear localization of p65, a subunit of NF-κB [71].