For example, when the seed “microgliosis” was used as the input, AD-associated genes “APP,” “PSEN1,” “PRNP,” “PSEN2,” “APOE,” “TNF,” and “VEGFA” ranked at the top 0.004%, 0.02%, 0.04%, 0.10%, 0.38%, 0.39%, and 0.59% among a total of 23,995 prioritized genes, respectively. The gene discussed is APOE; the disease is Alzheimer disease.