CD8A and cancer: This could be partly explained by the findings from Ford et al. that CAFs modulate immunotherapies resistance specifically by discharging CD8 + T cells from tumor mass to tumor margin [60], meanwhile, the remodeling ECM constructed interactively by CAFs and cancer cells serve as the physical hamper against the penetration of tumoricidal immune cells as well as the delivery of anticancer agents to solid tumors [20, 61].