Particularly, these included four Hif1α target genes (i.e. POSTN, TNFSF13B, PPEF1 and SAMSN1) that were significantly up-regulated in VHL-KO RENCA, and are of poor prognosis for RCC patients (Supplementary Fig. S4b). This evidence concerns the gene SAMSN1 and renal cell adenocarcinoma.