In this study, although the significant correlations between IR and CK18 (r = 0.160, P = 0.025) or liver fibrosis (r = 0.110, P = 0.026) were observed through correlation analysis, HOMA-IR is not confirmed as an independent predictor for liver fibrosis in CHC with T2DM. This evidence concerns the gene KRT18 and cryohydrocytosis.