For predicting advanced fibrosis and cirrhosis, the AUC values of FIB-4 + CK18 (AUC 0.74 [95% CI 0.65, 0.83], 0.77 [95% CI 0.69, 0.86], respectively) were significantly higher than those of FIB-4 (AUC 0.61 [95% CI 0.51, 0.71], P = 0.02; 0.61 [95% CI 0.51, 0.71], P = 0.03). Here, KRT18 is linked to fibrosis.