TRAF6 and neoplasm: A recent study suggested that FOXP3 activates the expression of miR-146 to prevent the activation of NF-κB by suppressing the expression of Irak1 as well as Traf6, causing the apoptosis of tumor cells and suggesting the presence of a FOXP3-miR-146-NF-κB pathway in the pathogenesis of prostate cancer (Liu et al. 2015).