The density of receptors on the cell surface and the binding affinity of the IFN-α subtypes with them are directly related to the different responses triggered by the cytokine binding with the receptor.14Therefore, it may be that the number of women who expressed the receptors in the group of CINIII lesions and invasive carcinoma was not enough to generate a local IFN-α response. This evidence concerns the gene IFNA1 and invasive carcinoma.