Highly expressed lncRNAs including SNHG1, SPRY4-IT1, H19, LINC00152, MALAT1, AFAP1-AS1, NEAT1, UCA1, HOTAIR, CCAT1, FAM83H-AS1, TUG1, ANRIL, HIF1A-AS1, PVT1 that are associated with the diagnosis of lung cancer also have a diagnostic value in other malignant tumors. The gene discussed is HOTAIR; the disease is lung cancer.