DCM: dilated cardiomyopathy; NYHA: New York Heart Association; LVEF: left ventricular ejection fraction; LVEDD: left ventricular end-diastolic dimension; NT-proBNP: N-terminal pro-B-type natriuretic peptide; ARNI: angiotensin receptor enkephalinase inhibitor; ACEI: angiotensin converting enzyme inhibitor; ARB: angiotensin receptor blocker. The gene discussed is ACE; the disease is dilated cardiomyopathy.