Superimposing streptozotocin-induced diabetes on fast food fed, growing Landrace pigs did induce severe cardiometabolic abnormalities like hyperglycemia, hypertriglyceridemia, hypo-insulinemia, increased plasma NEFA, lactate and TNF-α concentrations, high liver and kidney weights, high aorta fatty streak percentage and a low pancreatic beta cell mass, all related to the pathophysiology of obese type 2 diabetes in humans. Here, TNF is linked to diabetes mellitus.