First, we assessed whether circadian genes identified in myotubes from NGT and T2D donors (identified by RAIN) were associated with BMAL1 and CLOCK binding to homologous mouse genes (Fig. 5A; Fisher’s exact test, FDR < 0.05; Jaccard index indicates the percentage overlap between circadian genes and BMAL1/CLOCK bound genes). Here, CLOCK is linked to type 2 diabetes mellitus.