Outside of the core-clock TFs, a large cluster of TF-gene interactions was observed within the RELA proto-oncogene, NF-kB subunit (RELA) TF-associated gene network in NGT, but not T2D, while nuclear factor kappa B subunit 1 (NFKB1)-related TF-gene interactions were observed exclusively in myotubes from T2D donors (Fig. 7B). This evidence concerns the gene RELA and type 2 diabetes mellitus.