To investigate whether this up-regulation of MMP3 was present in human disease, tissue lysates from the frontal cortex of nondemented controls and patients with Frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17T) with +3 or P301L MAPT mutations, or Pick’s disease, or from the midbrain of patients with PSP were immunoblotted for MMP3 (Fig. 6, C and D). Here, MMP3 is linked to Pick disease.