Neuroblastomas in patients and experimental cell lines generally have one of two CRC modules: the immature neural crest–like or mesenchymal subtype, defined by high expression levels of the PRRX1, YAP/TAZ, and AP-1 transcription factor genes, or the more commonly observed adrenergic CRC, characterized by high expression levels of HAND2, ISL1, PHOX2B, GATA3, TBX2, and ASCL1 (12–14). This evidence concerns the gene HAND2 and colorectal carcinoma.