HAND2 and colorectal carcinoma: Our results indicate that the collective activity of the adrenergic CRC, including HAND2, ISL1, PHOX2B, GATA3, ASCL1, and TBX2, is essential for maintaining the high oncogenic expression level of MYCN, likely through activation of enhancers associated with the MYCN gene that are included in the amplified sequences (31, 32).