Thus, ATRA initiates a change in cell state of neuroblastoma cells corresponding to a shift from the adrenergic CRC to a new retino-sympathetic CRC, which includes RARA, HAND2, ISL1, TBX2, TBX3, MEIS1, and SOX4 (Fig. 7 and table S1). Here, ISL1 is linked to colorectal carcinoma.