The adrenergic CRC consists of an interdependent autoregulatory network that includes HAND2, ISL1, PHOX2B, GATA3, ASCL1, and TBX2 and is essential to drive the expression of MYCN and to facilitate the growth and survival of MYCN-amplified neuroblastoma cells (14, 19). This evidence concerns the gene ISL1 and neuroblastoma.