To determine the effects of BRD2889 on this axis and on PH in vivo, low (5 mg/kg) and high (10 mg/kg) doses of BRD were administered in a disease reversal protocol to a group 1 PAH mouse model (hypoxic IL-6 Tg mice), which also demonstrated increased lung GST activity with PAH (fig. This evidence concerns the gene IL6 and pulmonary arterial hypertension.