As in PAH rats, we observed an amelioration of PH indices, including reduced pulmonary vascular muscularization (via α-SMA stain; Fig. 5, A and B) and RVSP (Fig. 5C), without significant effect on Fulton index (Fig. 5D) or heart rate (fig. The gene discussed is ACTA1; the disease is pulmonary arterial hypertension.