Casar-Borota et al. [4] examined 30 aggressive PitNET and 18 pituitary carcinomas and found negative immunostainings for ATRX protein (Alpha thalassemia/mental retardation syndrome, x-linked) in 13% of aggressive PitNETs and in 28% of carcinomas. This evidence concerns the gene ATRX and alpha thalassemia spectrum.