In both brain regions, a sex-stratified differential gene expression (DGE) analysis was performed comparing AD cases to controls, with APOE genotype as a covariate, in astrocytes (Ast), microglia (Mic), excitatory neurons (Ex), inhibitory neurons (In), undifferentiated neurons (Neu), oligodendrocytes (Oli), and OPCs (Supplementary Tables 3 and 4). This evidence concerns the gene APOE and Alzheimer disease.