When it comes to clinical factors, apart from CHA2DS2-VASc scale, chronic kidney disease was related to the higher prevalence of LAA thrombus in the study of Kaplon-Cieslicka et al., while Zhou et al. proved that red cell distribution width and NT-proBNP level would be other risk factors of LAA thrombus formation [27, 28]. The gene discussed is NPPB; the disease is chronic kidney disease.