Also, for the human system, the relevance of circadian clock-controlled gene expression regarding anthracycline cardiotoxicity could be demonstrated in embryonic stem cell-derived cardiomyocytes, which showed an oscillating circadian pattern in the strength of the apoptotic response after Dox treatment [11], confirming our notion that combined effects of the underlying cancer disease and the oncological treatment should be considered when analyzing cancer-related cardiotoxicity [34]. This evidence concerns the gene CLOCK and cancer.