Type I IFNs play a critical role against viral infection involving IFN-β and various IFN-α subtypes; importantly, IFN-α and IFN-β have the common receptor IFNAR, the specific binding sites separately and different affinity with IFNAR direct to variant functions (19), IFN-α may have a key role in viral resistance in vivo. Here, IFNAR1 is linked to viral infectious disease.