Some variants associated with T2D, such as HNF1A p.I27L, IDE3 p.T105A, IRS1 p.S892G, and INSR p.A2G, although considered benign and determining quite conservative biochemical changes in the amino‐acid sequence, could influence the activity of the related proteins [37, 38, 39, 40, 41]. The gene discussed is INSR; the disease is type 2 diabetes mellitus.