In this light, lacking solid background data to prioritize these variants, we built a simple and intuitive score based on the sum of the number of genetic variants involved in both T2D and CRC (CCND2, CDKN1B, CDKN2A, CDKN2B, CENPA, EML4, ID3, HNF1A, IGF1, IGF2, IGF1R, INSR, IRS1, IRS2, and TCF7L2). This evidence concerns the gene IRS1 and type 2 diabetes mellitus.