In contrast, several studies highlighted p53‐dependent repression of Myc through the transcriptional activation of an isoform of Pvt1, called Pvt1b, and determined the importance of this axis in mediating p53 tumor‐suppressive function (Barsotti et al., 2012; Olivero et al., 2020; Porter et al., 2017; Figure 7b, Model 3). Here, PVT1 is linked to neoplasm.