While subsequent studies have questioned both the role of HOTAIR in HOXD regulation (Amandio et al., 2016; Li et al., 2013; Schorderet & Duboule, 2011) and the specificity of the HOTAIR‐PRC2 interaction (Davidovich et al., 2013; Portoso et al., 2017), investigations of HOTAIR in the context of cancer have suggested an intriguing role in promoting metastatic progression through a related mechanism. Here, HOTAIR is linked to cancer.