Fluorescent immunostaining combined with quantitative analysis clearly illustrated that the percentage of p‐Tau Thr231/BMAL1 co‐stained cells was increased significantly in the RSC of AD (p < 0.0001) and WT (p < 0.05) mice after CSD (Figures 4C, c‐3). This evidence concerns the gene BMAL1 and Alzheimer disease.