TRPV1 and peripheral neuropathy: While future studies are needed to gain insight into the possible interaction of CBRs and TRPV1 in bortezomib-induced peripheral neuropathy, taking into account that TRPV1 sensitization is one of the aspects of bortezomib-induced neurotoxicity [45], it is interesting that CB2R has been found to colocalize with TRPV1 in avulsed human DRG neurons [52] and that CB2R agonists diminish TRPV1 activation by depleting cAMP levels [52, 53].