IL6 and metabolic dysfunction-associated steatohepatitis: First, there was a ten-fold increase in IL6 levels following NM exposure in the NASH MT as compared to steatosis MT (i.e., 13 day exposure of TiO2 NMs at 10 μg/ml—steatosis MT 35.49 ± 1.44 pg/ml vs. NASH 438.8 ± 33.1 pg/ml), and this was sustained across all timepoints (Fig. 5a, b).