CD68 and metabolic dysfunction-associated steatohepatitis: Interestingly, particularly in the NASH condition, agglomerates of CD68-positive cells form ring structures around degenerated hepatocytes, also known as hepatic crown-like structures (hCLS), which has been described as a histopathological feature in non-alcoholic steatohepatitis in mice and human (Itoh et al. 2013).