INS and metabolic dysfunction-associated steatohepatitis: The ATP drop in steatotic and NASH MTs, which has also been observed in the steatotic liver of type 2 diabetic patients, suggests a metabolic stress response, either insulin resistance and/or mitochondrial disfunction which for steatosis stabilizes between day 7 and 14, but further progresses for the NASH conditions (Supplementary Fig. 2a).