Indeed, neurological phenotypes have been described for several other CaMKII mutations with similar or less severe biochemical effects, including (i) E183V, which disrupts T286 autophosphorylation and is linked to autism spectrum disorder (Kury et al., 2017; Stephenson et al., 2017), and (ii) P212Q, which causes increased T286 autophosphorylation and is associated with seizures (Akita et al., 2018; Kury et al., 2017). Here, CAMK2G is linked to autism spectrum disorder.