The methylation-dependent repression of TACC2 and HOXA9 in UV-MCC cell lines is likely to be achieved in VP-MCC cell lines by other means; the Simian virus 40 (SV40)-encoded LT inhibits TACC2 protein function and HOXA9 is a target of EZH2/SUZ12-based repression [26, 50–52]. This evidence concerns the gene TACC2 and Merkel cell skin cancer.