Many antiarrhythmic drugs used in AF patients are P-gp inhibitors (e.g., verapamil, diltiazem, dronedarone, amiodarone, and quinidine), others (some antibiotics, antiviral drugs, fungistatic, anticancer and antiepileptic drugs) are strong inhibitors of CYP3A4. This evidence concerns the gene CYP3A4 and atrial fibrillation.