C8B and argyrophilic grain disease: Immune activation was evident from 7 dpi with complement activation (DRE-166658, FDR 0.0178) involving ten genes (crp, c6, c8a, c8b, c8g, c9, cpb2, hbl3, masp1, masp2) and is consistent with what was found in the proteome analysis of AGD-affected gill in our laboratory26.