With regard to the down-regulation of genes with involvement in cytokine and interleukin signalling, interrogation of the DEG dataset identified multiple transcripts from nine interleukin (il) gene families with differential expression in AGD-affected gills, with one gene il-17a/f1-like (Gene ID 106600843) was found to be down-regulated at every time point. The gene discussed is IL17A; the disease is argyrophilic grain disease.