TGFB1 and neoplasm: For tumor formation and progression, several signaling pathways were found, including genes related to epidermal growth factor receptor (EGFR), transforming growth factor-beta 1 (TGFβ), interleukin, the Janus kinase/signal transducers and activators of transcription (JAK/Stat), apoptotic, angiogenetic, and inflammatory signaling pathways.