In sum, we suggest that SHH-subgroup medulloblastoma exhibits preserved intratumoral heterogeneity marked by a developmental gradient from “stroma-active” cells, characterized by high expression of SHH-stroma-drivers, high developmental potential, cycling cells, and enrichment of the EMT program to “stroma-inactive” cells, characterized by low expression of SHH-stroma drivers, less developmental potential, and enrichment of neurodevelopmental programs. The gene discussed is SHH; the disease is medulloblastoma.