NR4A2 and placental insufficiency: Knockdown of NR4A2 under hypoxia significantly increased expression of NLR family pyrin domain containing 3 (NLRP3), a master regulator of the inflammasome (p = 0.0065; Fig. 6d) and Serine Peptidase Inhibitor, Kunitz Type 1 (SPINT1), associated with placental insufficiency (p = 0.0056; Fig. 6e).