A key aim of this paper was to identify whether expression of NR4A2 in the pathological placenta mirrored the increased NR4A2 transcripts demonstrated in the maternal circulation of cases of preterm preeclampsia and growth restriction (< 34 weeks gestation)—if so, supporting the concept that they may originate in the dysfunctional placenta. This evidence concerns the gene NR4A2 and preeclampsia.