However, oral administration of NK210, NK219, or Mx decreased cognitive impairment-like behaviors, NF-κB+/Iba1+ cell population, and TNF-α and IFN-γ expression in the hippocampus, while BDNF+/NeuN+ cell population and IL-10 expression increased. The gene discussed is NFKB1; the disease is Cognitive impairment.