In conclusion, NK210, Lactobacillus sp, and NK219, Bifidobacterium additively or synergistically control IFN-γ to IL-10 and TNF-α to IL-10 expression ratios in the host with and without immune imbalance, resulting in the alleviation of gut dysbiosis, inflammation, and cognitive impairment. This evidence concerns the gene IFNG and Cognitive impairment.