However, oral gavage of NK210 and/or NK219 suppressed cyclophosphamide-induced colitis: they increased IFN-γ, TNF-α, and IL-10 expression, but decreased myeloperoxidase activity and IFN-γ to IL-10 and TNF-α to IL-10 expression ratios in the colon. The gene discussed is TNF; the disease is colitis.