HMGCR and obesity due to melanocortin 4 receptor deficiency: It has been reported that curcumin and CurNPs can revert the aggravated serum lipid profile through lowering these secondary complications; obesity, adipogenesis, HMG-CoA reductase, cholesterol absorption, and intestinal transmission, lipogenic genes expression, raising LDL receptors and controlling some genes implicated in lipoprotein and lipid metabolism46,47.