MAP2K7 and type 2 diabetes mellitus: In the present study, the activation of ERK, MEK, and p38 MAPK in the liver of T2D-induced rats was significantly suppressed by the administration of both nanoparticles so that 10 mg/kg CurNPs and 50 mg/kg ZnONPs treatments were more effective compared to other doses and curcumin, ZnSO4 as well as metformin.